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Bio-Thera Solutions Ltd

Bio-Thera Solutions, Ltd. is a biopharmaceutical company that researches and develops novel therapeutics for cancer, autoimmune, cardiovascular, and eye diseases, as well as other severe unmet medical needs in China and internationally. Its marketed products include QLETLI for ankylosing spondylitis, rheumatoid arthritis, psoriasis, Crohn's disease, and uveitis; POBEVCY for metastatic colorectal cancer, non-squamous non-small cell lung cancer, recurrent glioblastoma, metastatic renal cell carcinoma, cervical cancer, and epithelial ovarian, fallopian tube, or primary peritoneal cancer; TOFIDENCE for rheumatoid arthritis, polyarticular and systemic juvenile idiopathic arthritis, and cytokine release syndrome; and BETAGRIN for acute coronary syndromes. The company also develops biosimilar drug candidates such as BAT2206 for psoriasis, Crohn's disease, and ulcerative colitis; BAT2306 for plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis; and BAT4406F, BAT6026, BAT2606, and BAT2506 for various autoimmune diseases. In addition, it develops BAT4306F, BAT1308, BAT1006, BAT4706, BAT6026, BAT7104, BAT8006, BAT8010, BAT8008, and BAT8007 for oncology; BAT2094 and BAT6024 for cardiovascular diseases; and BAT5906, which is in Phase III clinical trials for wet age-related macular degeneration and diabetic macular edema (DME). The company has a biosimilars alliance with STADA Arzneimittel AG for tocilizumab, an immunosuppressant monoclonal antibody indicated for certain inflammatory conditions, and collaborates with Avalon Pharmaceuticals on BAT2406, a biosimilar of Dupixent (dupilumab), in Saudi Arabia and other Middle Eastern and North African markets. Bio-Thera Solutions, Ltd. was founded in 2003 and is headquartered in Guangzhou, China.

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Bio-Thera Solutions posts first-half loss of 252 million yuan; debt-to-asset ratio climbs to 95%

Bio-Thera Solutions released its 2026 interim report, showing first-half operating revenue of 519 million yuan, up 17.35% year on year, but a net loss of 252 million yuan, with the loss widening from a year earlier. As of the end of the reporting period, net assets attributable to shareholders of the listed company stood at 124 million yuan, down 67.04% year on year, while the debt-to-asset ratio rose to 95%. First-half research and development spending totaled 468 million yuan, accounting for 90.34% of operating revenue. Bio-Thera Solutions' marketed products include adalimumab and bevacizumab, among others, with additional products in development or under regulatory review. The company's rising debt-to-asset ratio had already drawn attention in an inquiry letter regarding its 2025 annual report, when the ratio stood at 83.56% at the end of 2025. The company explained that the increase was mainly because licensing revenue was recorded as contract liabilities; excluding that item, the ratio was 46.18%.
688177.CG · Capital · Negative First-half net loss widened to 252 million yuan and debt-to-asset ratio climbed to 95%, reflecting deteriorating financial health.
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688177.CG▲

Lepu Medical Plans to Apply for 315 Million Yuan M&A Loan

Lepu Medical announced that its board of directors has approved a proposal to apply for an M&A loan of no more than 315 million yuan from Industrial Bank. The loan will be used to pay or replace the transfer payment for all intangible assets involved in Lepu Pharmaceutical's acquisition of Betanin from Bio-Thera Solutions as the marketing authorization holder, including the drug marketing license, intellectual property, production technology, and commercialization rights.
688177.CG · Capital · Positive Bio-Thera Solutions is selling intangible assets, receiving payment that strengthens its balance sheet.
601166.CG · Capital · Positive Industrial Bank is providing the M&A loan, generating fee income and interest revenue.
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China
Biotech & Genomic Medicine▲

Bio-Thera Solutions' Bevacizumab Injection Approved for Additional Hepatocellular Carcinoma Indication

Bio-Thera Solutions announced that the company recently received a drug supplementary application approval notice from China's NMPA for its bevacizumab injection Pubeixi. The drug has been approved for an additional indication, hepatocellular carcinoma. With this approval, Pubeixi has now been approved for six indications in China. Commercial licensing partnerships for the drug now cover 104 countries and regions worldwide.
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Biotech & Genomic Medicine › Biosimilars Competition
688177.CG · Regulation · Positive NMPA approval for additional hepatocellular carcinoma indication expands approved uses.
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Bio-Thera Solutions expects first-half 2026 loss to widen to between 230 million and 290 million yuan

Bio-Thera Solutions issued an announcement, projecting a net loss attributable to the parent company of between 230 million and 290 million yuan for the first half of 2026, an increase in loss of 105 million to 165 million yuan compared with the same period last year. After deducting non-recurring items, the net loss attributable to the parent is expected to be between 240 million and 300 million yuan, a year-on-year increase in loss of 68.8 million to 129 million yuan. The change in performance is mainly due to steady growth in sales of adalimumab injection and tocilizumab injection, with operating revenue rising by 60 million to 90 million yuan year-on-year, an increase of 13.58% to 20.37%, but research and development expenses are expected to increase by 100 million to 140 million yuan, a year-on-year rise of 28.67% to 40.14%, leading to a wider loss. In the first quarter of 2026, the company achieved revenue of 252 million yuan and a net loss attributable to the parent of 152 million yuan.
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Biotech & Genomic Medicine › Biosimilars Competition
688177.CG · Capital · Negative Company expects wider net loss due to rising R&D expenses outpacing revenue growth.
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