Pfizer Reports Positive Phase 2 Results for Eczema Drug Tilrekimig

โดย Benzinga·US·Read original
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Pfizer Inc. on Thursday presented detailed Phase 2 results showing its experimental eczema drug tilrekimig (PF-07275315) achieved significant skin clearance in adults with moderate-to-severe atopic dermatitis. The ongoing trial met its primary endpoint, with a statistically significant increase in participants achieving EASI-75 at Week 16 across all evaluated doses compared to placebo. In Stage 1, subcutaneous tilrekimig at 450 mg every two weeks produced EASI-75 in 62.5% of patients versus 19.9% for placebo, while Stage 2 monthly dosing of 400 mg, 200 mg, or 50 mg yielded EASI-75 rates of 58.5%, 61.0%, and 47.8%, respectively, representing absolute improvements of 49.4%, 51.9%, and 38.7% over the 9.1% placebo rate. Key secondary endpoints measuring clear or almost clear skin showed 30.3% achievement in Stage 1 versus 11.8% for placebo, and 26% to 27% across monthly cohorts in Stage 2 versus 0% for placebo. Tilrekimig is a potential first-in-class trispecific antibody targeting IL-4, IL-13, and TSLP, with an extended half-life of approximately 37 days supporting monthly dosing, and was well-tolerated with no dose-dependent safety signals. Pfizer shares were down 1.23% at $28.17 at the time of publication.

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Pfizer's experimental eczema drug tilrekimig met its Phase 2 primary endpoint with significant skin clearance, a positive R&D/trial result.

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