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H. Lundbeck A/S

H. Lundbeck A/S researches, develops, manufactures, and commercializes pharmaceuticals for psychiatric and neurological disorders in Europe, the United States, and internationally. Its marketed products include Abilify Maintena/Abilify Asimtufii for schizophrenia and bipolar I disorder in adults, Brintellix/Trintellix for depressive disorders, Rexulti/Rxulti for major depressive disorder and schizophrenia, Vyepti for migraine prevention, and Cipralex/Lexapro for depression. The company also provides Northera for symptomatic neurogenic orthostatic hypotension, Onfi for epilepsy, Sabril for refractory complex partial seizures and infantile spasms, Ebixa for dementia, Azilect for Parkinson's disease, Xenazine for chorea, Deanxit for depression, Cipramil for depression and anxiety, and Cisordinol for psychosis. Its development pipeline includes Eptinezumab for migraine prevention and in phase 3 for cluster headache, Lu AG09222 in phase 2 for migraine prevention, Lu AG13909 in phase 1 for neurohormonal dysfunctions, Brexpiprazole for post-traumatic stress disorder, Lu AF28996 in phase 1 for Parkinson's disease, the MAGLi program in phase 1 for neurology, Bexicaserin in phase 3 for developmental and epileptic encephalopathies, Amlenetug in phase 3 for synucleinopathies, and Lu AG22515 in phase 1 for neurology. Lundbeck has a strategic research collaboration with Contera Pharma to develop oligonucleotide-based medicines for patients with serious neurological conditions. The company was founded in 1915 and is headquartered in Valby, Denmark.

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0ABR.LSE

Lundbeck Approaches Xeris Biopharma Over Potential Takeover

H Lundbeck has expressed interest in a potential takeover of Chicago-based commercial-stage drugmaker Xeris Pharmaceuticals Inc, according to people familiar with the matter cited by Bloomberg. The Danish pharmaceutical group has been working with financial advisers to explore an acquisition of the U.S. firm, though discussions remain preliminary and may not result in a formal transaction. Shares of Xeris have surged almost 20% over the past 12 months, lifting the company's market valuation to approximately $1.8 billion, while Lundbeck holds a market capitalization of roughly 43.3 billion Danish kroner, or $6.6 billion. A spokeswoman for Xeris told Bloomberg that the company is "not for sale" and remains "laser focused on improving patient lives by developing and commercializing" its therapeutic portfolio, which centers on endocrine and rare diseases and three approved treatments, including Recorlev for Cushing's syndrome. Any deal would expand Lundbeck's footprint into rare endocrine disorders and specialized formulation technologies, beyond its traditional focus on neurological and psychiatric conditions such as Parkinson's disease and schizophrenia.
0ABR.LSE · Capital · Neutral Lundbeck is working with advisers on a possible acquisition of Xeris, but talks are preliminary and may not result in a deal.
XERS · Capital · Positive Lundbeck is exploring a potential takeover of Xeris, a financial/M&A event that could deliver a premium to Xeris shareholders.
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Biotech & Genomic Medicine▲

AbbVie, argenx, Lundbeck and Takeda Join Antibody Developability Consortium

Ginkgo Datapoints, an offering of Ginkgo Bioworks, and Apheris GmbH announced that the Antibody Developability Consortium has launched with AbbVie, argenx, Lundbeck, and Takeda as founding members. The industry collaboration aims to build the field's largest standardized antibody developability dataset, with each founding member contributing proprietary antibody sequences and Ginkgo Datapoints filling any remaining capacity from publicly available sources to reach 10,000 antibodies in total. Using Apheris' federated infrastructure, members can train, benchmark, and refine AI models on the full consortium dataset without exposing their raw proprietary sequences to other members, and they retain ownership of the sequences and assay data they contribute. Ginkgo Datapoints leads the scientific design and execution, including sequence selection, antibody production, and high-throughput wet-lab characterization, and trains a foundation antibody developability model within Apheris' secure environment. Charlotte Deane of the University of Oxford and Peter Tessier of the University of Michigan will provide independent scientific oversight, and the consortium's initial dataset is targeted for delivery to members by early 2027.
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DNA · Demand · Positive Ginkgo Datapoints leads the consortium's scientific design and execution, gaining a major industry collaboration with four pharma founding members.
Apheris · Demand · Positive Apheris provides the federated infrastructure enabling consortium members to train AI models without exposing proprietary sequences.
0ABR.LSE · Technology · Positive Lundbeck joins as founding member of the consortium, contributing proprietary antibody sequences to advance AI developability models.
4502.JP · Technology · Positive Takeda joins as founding member of the Antibody Developability Consortium, contributing proprietary antibody sequences for AI model training.
ABBV · Technology · Positive AbbVie joins as founding member of the Antibody Developability Consortium, contributing proprietary antibody sequences to build a standardized developability dataset and AI models.
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