Aktis Oncology, Inc. is a clinical-stage oncology company focused on the research, development, and commercialization of targeted radiopharmaceuticals for solid tumors. Its lead candidate, [225Ac]Ac-AKY-1189, is a miniprotein radioconjugate in Phase 1b trials for Nectin-4 expressing solid tumors, including urothelial, breast, NSCLC, colorectal, and cervical cancers. Another candidate, [225Ac]Ac-AKY-2519, targets B7-H3 (CD276) expressing tumors such as prostate and lung cancers. The company has license and collaboration agreements with Protein Innovation, Inc., TRIUMF Innovations, Inc., and Eli Lilly. Formerly HotKnot Therapeutics, Inc., it changed its name to Aktis Oncology, Inc. in April 2020, was incorporated in 2020, and is headquartered in Boston, Massachusetts.